An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’

In this current review, research spanning the last decade (such as transcriptomic studies, phenotypic observations, and confirmed comorbidities) has been synthesized into an updated etiology of hair loss applied to new cosmeceutical paradigm rejuvenation. The major etiological components in scalps with are denoted ‘big eight strikes’, which include following: androgens, prostaglandins, overactive aerobic metabolism glucose, bacterial or fungal over-colonization, inflammation, fibrosis, circulation problems, malnutrition. relevance eight’ nine categories is explained. cases androgenetic alopecia female pattern loss, both elevated DHT increased frequency androgen receptors lead problems glucose (sugar), redox imbalance, disruption electron transport chain, PPAR-γ overactivity (the latter unique alopecia, where reverse occurs other types loss). These factors others from ‘the big focal point our hypothetical narrative attenuative mechanisms commercial serums. We conclude that cosmeceuticals potential improve all strikes (according published vitro clinical data) utilize bioactive peptides plant compounds either flavonoids (isoflavones, procyanidins, flavanols, flavonols) sterols/triterpenes. It noteworthy many therapeutic interventions generic multiple loss. Lastly, suggestions made on how scalp health can be improved by following approach.